Nutramax LaboratoriesDenamarin Liver Health Supplement for Small Dogs and Cats - With S-Adenosylmethionine (SAMe) and Silybin, 30 Tablets

I have 2 cats which I adopted in 2010 that spent the first 3.5 years of their life with chronic diarrhea, on and off metronidazole during that time, only for the diarrhea to return shortly after the antibiotic was stopped. Stools were always negative, but I found out my one cat had sky-high liver enzymes. I tried this (one pill for each cat at bedtime) and they had perfect poop within about 2 days. Also, my cat's liver enzymes quickly returned to normal.I treated the cat with the high liver enzymes for about 3 months and stopped. Both cats still had perfect poop, but the cat who had the sky-high liver enzymes in the past (at some point) started hiding under a comforter on the chair all day (which was not like him), and when I'd peek under I could just tell he wasn't feeling well. I didn't take him to the vet because he'd always act perky at mealtime. (In retrospect, I believe he started hiding around the time I stopped the Denamarin.)Fast forward to now, 2016...My husband & I started giving them bits of table food because we couldn't resist their begging - perhaps the trigger? Both cats developed diarrhea again and were treated by a new vet with metronidazole & amoxicillin (both positive for clostridium). Looking back in their records, they were positive for this in the past, but vets only ever treated them with metronidazole and never mentioned anything about clostridium to me. I was hopeful that clostridium had been been the cause all along and that these 2 antibiotics together would finally rid them of diarrhea forever, but even after a round of this combination, they still had stools the consistency of pudding. When I asked for another round of antibiotics, the vet refused and told me to take them both to a specialist and recommended (VERY expensive) endoscopies. I had already spent so much money in the past on stool tests, even a comprehensive and expensive stool test, probiotics, digestive enzymes, various cat foods, etc... Nothing ever helped.So I decided to start them both on Denamarin again - one pill at bedtime for each - and their stools were perfect again within 2 days.This stuff is nothing short of a MIRACLE for cats with CHRONIC DIARRHEA. I've therefore decided I will be giving them this f-o-r-e-v-e-r, and of course, resist giving them any table food. :-/+++++UPDATE (November 2017)...additional information...This is nothing short of a miracle for acute and chronic diarrhea in cats. I have two cats who had acute and chronic diarrhea from the day I brought them home from a shelter as kittens. THREE & A HALF YEARS of stool testing, even an expensive 'comprehensive stool panel' on the one who always got the sickest, all negative except a toxin present for clostridium perfringens, which the vet blew off as 'harmless' and not the cause. Both cats would always be prescribed a course of Metronidazole, so I knew a 'bug' was involved. Metronidazole would help firm them up some in the sickest cat, completely in the other cat, but then back to the mashed potato poop and squirts in no time. Whether or not it was this 'harmless' bacteria or not, I have no idea. I was told it must be 'food allergies', but tried every limited ingredient canned cat food I could find to no avail. And BOTH cats supposedly had food allergies even after stopping the tidbits of table food?My one cat, when tested, had high liver enzymes, 5 times higher than normal. I spent many nights googling how to bring his liver enzymes down. That is how I first came across Denamarin. He honestly looked like he was dying. ONE PILL and within the next day or two he had his FIRST normal bowel movement in his LIFE. I can't believe he had to live the first 3 1/2 years of his life sick like this. He was the one who would always get the sickest, but eventually if one had diarrhea, the other one would get it too. I will give him one pill for the rest of his life because when I stop, within a couple of months he'll start look sickly and eventually have an acute bout of diarrhea, turning chronic, the other cat contracting it soon after.During the time period I had stopped giving this one cat Denamarin, he developed one of these horrible bouts of diarrhea (the other cat soon after). He wouldn't eat, would pace and pant until he threw up to the point of dehydration, and would run to the litter box with the squirts, runs, mushy poop. Took him to an emergency veterinary hospital, and all they gave him was an anti-nausea medication, something to calm his stomach, and sub-q fluids. Next day he had diarrhea still. I called the hospital, and this vet refused to prescribe Metronidazole even though I'd just paid $530. So I pulled out the Denamarin...diarrhea gone the next day.Just last night I noticed the other cat had formed, but soft stool, mushy at the very end. I panicked and gave him a Denamarin. He didn't poop at all today.Denamarin is a MIRACLE, and if you have a cat in this situation...chronic or acute diarrhea, routine stool tests negative or comprehensive stool panels positive for ANY so-called 'harmless' bacteria or bacterial toxin, this is worth a try. Seriously, I love this stuff so much, I could do a commercial for it. I'm posting this, not because I'm positive it will help every cat, but I plead with anyone in similar situations to give this a try. I am convinced this pill saved my one cat's life. I give it to him daily, and I watch the stools of my other cat and may even start giving it to him daily as a precaution.

Helpful to my Dog! Price is much better than Vet.

SOMETHING in my initial review didn't meet Amazon's "standards", so I'm rewriting. This seems to help my cat. I'm lucky that my cat is easy to pill. Since I've been using it, his blood functions have improved. Good stuff.

Over two years ago my dog (then three years old) was going into renal failure. I lost a dog to it before, (senior foster dog with unknown past) but none of the same factors were at play here. I was so scared because I was so helpless before. Milk thistle was mentioned this time, I did the reading on it, & due to my dog's plant allergies I decided to give this a try. It is expensive, but WELL worth it. With in a couple weeks her values were back in normal range. We kept her on it daily for over a year. For about a year now we've given it to her about every other day & she is still doing great in regards to her liver.It improved her health so much that it inspired me to find the money to start myself on milk thistle extract and I have had some noticeable health benefits too. (My liver values weren't even "out of range.") (e.g. I have a severe alcohol allergy and even if a tiny amount is in food I'd get violently ill. food poisoning ill, headaches, and my abdomen would be stiff for a day or two. Now being on the milk thistle, a tiny bit of alcohol in food only gives me mild discomfort.)I would highly recommend Denamarin not only for pets on the brink of death, but as part of a regular maintenance regiment for healthy pets. (Given as often as you can afford. Even if it is just once per week.)These do taste awful! My dog can't stand the taste of them. I can't hide them in anything. I have to push it down her throat. They did her so much good though that if I forget, she reminds me at that time every day. (Helps that I had lots of practice on a bigger dog years ago for another pill.)Though it says an hour between the pill & food, I've heard others say that it works better if it's two hours. I pushed it out to three hours when we can. I do give her a very tiny piece of treat in about two teaspoons of water in her bowl after pilling her to make sure it goes down all the way.I wanted to leave a positive review for this product much sooner, but kept forgetting. I wish I could leave something more articulate. I would give this product a five star review several times over. (This coming from a person who denounces most pharmaceuticals. My own Dr. has a hard time convincing me to take anything.)